I have had tip tanks on my 250 for years. The only thing I have noticed is a very slight increase in IAS at and above 8000 feet.
I would also suggest that you also strongly consider an Aero-Trim electric aileron trim tab (
http://www.aeroresourcesinc.com/store_/). Price is $795. Installation is fairly simple. The electric trim allows you to trim out a heavy wing for coordinated flight so you don't have to hold a constant pressure on the yoke, or, if you have an autopilot, it saves the servos running all the time to stop the roll. An imbalance in the fuel quantity in the tip tanks can result in quite a hand full. Trying to burn from both tips at the same time does not work (impossible on the models originally equipped with four tanks, but possible on the two tank models). What happens is that the fuel will transfer through the selector valves and down into the lower (in altitude) tank, making it even heavier and even more below the level of the other tank. Eventually, the lower tank will overflow and the fuel will go overboard.
This particular arrangement can be used to transfer fuel ON THE GROUND ONLY from one tip to the opposite main by selecting one tip and the opposite main. The fuel will run out of the tip, through the selector valves, and into the opposite main. This trick can be used to get an absolutely full main tank. The tips then have to be topped off again. It will only work on the early model 250's (1960 and earlier). It will not work on the later singles because the plumbing for the tank selection is different.
I hope this helps.
Hank