I've flown a lot of planes. C-150 through Turbo 210, Different varieties of Cherokees, and several twins. Of all the singles I've flown the Comanche 180 is my favorite.
It has delightful handling compared to the Cessnas and Cherokees. It has simple systems, and it's very economical to fly. The Lycoming O-360 is ultra reliable. I can run all day long at 135 to 140 knots while burning 9-10 GPH.
You should have no trouble with the transition other than remembering to put the gear down and a little finess on the landings.